12 Feb 2016 Scott A. Keith, Sarah K. Maddux, Yayu Zhong, Meghna N. Chinchankar, Annabel A. Ferguson , Arjumand Ghazi , Alfred L. Fisher. Graded Proteasome Dysfunction in Caenorhabditis elegans Activates an Adaptive Response Involving the Conserved SKN-1 and ELT-2 Transcription Factors and the Autophagy-Lysosome Pathway. PLoS Genet 12(2): e1005823. doi:10.1371/journal.pgen.1005823

Abstract The maintenance of cellular proteins in a biologically active and structurally stable state is a vital endeavor involving multiple cellular pathways. One such pathway is the ubiquitin-proteasome system that represents a major route for protein degradation, and reductions in this pathway usually have adverse effects on the health of cells and tissues. Here, we […]

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