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Clinical Research Core (CRC)

Core Functions. This Core, led by Nicolas Musi, MDDean Kellogg, MD, PhD and Sara E. Espinoza, MD, MSc, assists basic and clinical investigators in developing rigorous and appropriately powered clinical studies and trial concepts that will lead to innovative approaches to improve healthspan and lifespan, and facilitates implementation and execution of translational human studies and clinical trials by investigators.

The Core provides expertise and coordinated access to resources and technology in both the San Antonio OAIC and facilities throughout our institution to maximize the depth of phenotypic characterization relevant to aging in trial outcomes. Training in clinical research for early-stage faculty and those new to clinical research is also available. This Core is also available to provides research project consultation and planning, assistance with safety and regulatory compliance processes, facilitates research subject recruitment and retention, and coordinates relationships with relevant San Antonio OAIC Cores and other Core facilities of our institution.

The South Texas Aging Registry and Repository (STARR)

The South Texas Aging Registry and Repository (STARR) is a database and specimen resource of adult subjects from the South Texas community. De-identified repository data and samples are available to qualified investigators for future studies related to aging. Or, investigators may contribute de-identified specimens and data to the repository.

SA OAIC Standard Battery of Tests

The following tests should be considered for inclusion in SA OAIC clinical studies. Use of tests from this “standard battery” will facilitate comparisons among different OAIC studies. Depending on the study, some or all of the battery may be incorporated. Documents referenced are provided at the right sidebar of this page.

GENERAL EVALUATION:

  1. Anthropometry (Height, Body Mass, Abdominal Circumference)
  2. Activities of Daily Living and Instrumental Activities of Daily Living assessments (See GRAF-The Lawton Instrumental Activities of Daily Living Scale)
  3. Veterans VR-36 Health Status Questionnaire (See VR-36 form and How to score VR-36; KAZIS-The Veterans SF-36 Health Status Questionnaire; BRAZIER-Validating the SF-36 health survey questionnaire-new outcome measure for primary care)

PHYSICAL PERFORMANCE EVALUATION

  1. Hand Grip strength (See GRIP STRENGTH instructions + score sheet; TAEKEMA-Handgrip strength as a predictor of functional, psychological and social health)
  2. Gait Speed or 6 Minute Walk Test (See GAIT SPEED instructions + score sheet; 6 Minute Walk Test Instructions + Score Sheet; ATS Statement- Guidelines for the Six-Minute Walk Test)
  3. Short Physical Performance Battery (SBBP-three tests of physical function: habitual walking speed; time to rise from a chair and sit down five times (chair stands; and standing balance) (See Short Physical Performance Battery Protocol and Score Sheet)
  4. Minnesota Leisure Time Activity Questionnaire (MLTA-An interviewer-administered questionnaire to evaluate energy expenditure in leisure time physical activity) (TAYLOR-A questionnaire for the assessment of leisure time physical activities

COGNITIVE EVALUATION

  1. SLUMS or MoCA-global cognitive assessment (See SLUMS and MoCA forms; BUCKINGHAM-Comparing the cognitive screening tools-MMSE and SLUMS)
  2. EXIT25 or CLOX 1 and II-Executive function (See EXIT25 instructions and EXIT25-Executive Interview 25 form; CLOX test form; ROYALL-Clock drawing is sensitive to executive control-a comparison of six methods)
  3. Texas Assessment of Processing Speed (TAPS)-uses sorting and categorization as test of Executive function; has alternative forms to minimize learning effects with repeated administration (See TAPS instructions, A+B forms, and A+B scoring sheets)
  4. Geriatric Depression Scale-depression screen (See GDS-Short Form; GREENBERG-The geriatric depression scale (GDS))

CONSTIPATION EVALUATION

  1. PAC-SYM score (See PAC-SYM form; NERI-Confirmatory factor analysis of the patient assessment of constipation-symptoms (PAC-SYM) among patients with chronic constipation)

MICROVASCULAR FUNCTION

  1. Laser-Doppler Flowmetry with Local Heating-NO dependent vasodilation (noninvasive) (See CHOI-New approach to measure cutaneous microvascular function- an improved test of NO-mediated vasodilation by thermal hyperemia)

CARDIOVASCULAR EVALUATION

1.  Aortic Pulse Wave Velocity-compliance assessment (noninvasive) (See BOUTOUYRIE-Assessment of pulse wave velocity)