Dr. Frost and her lab have a new paper published in Cell Reports.
•TauR406W induces nuclear CREB depletion in neurons of the adult Drosophila brain
•Nuclear Ca2+ decreases with aging and tauopathy in the adult Drosophila brain
•Nuclear Ca2+ is depleted in iPSC-derived neurons from sporadic Alzheimer’s disease
•Pharmacologic/genetic manipulation of BK channels modify tauR406W neurotoxicity