The Pre-clinical Research Core plays a central role in the SA OAIC by providing the knowledge, skills, and technical support to assist OAIC investigators in using the common marmoset (Callithrix jacchus) as a pre-clinical model for aging interventions (mainly pharmacological). This core provides to OAIC investigators resources (including access to geriatric marmosets) and services to assist with pre-clinical translation projects, including reverse translational projects to develop novel marmoset models of age-related dysfunction.
This Core, led by Adam B. Salmon, PhD, and Cory Ross, PhD, supports pre-clinical (animal) projects that explore the basic biology of aging and evaluate interventions that target the aging process to enhance healthy aging, as well as to prevent and better treat aging-related diseases.
The Pre-Clinical Research Core can provide to OAIC investigators:
The Core can also provide functional and physiological assessments of aging marmosets that are unavailable elsewhere as well as the applicable expertise to work with investigators on developing potential projects using aging marmosets.
– Administration of nutritional or pharmaceutical interventions.
– Tolerability/safety of interventions.
– General physical parameters and animal monitoring.
– Hematologic assessment:
– Assessment of markers of healthspan
With our support, investigators have made major advances and novel discoveries in clinical translational geroscience, including:
Ongoing assessment of the effect of rapamycin on marmoset lifespan and healthy aging.
Identification of changes in the aging marmoset gut microbiome.
Identification of significant functional changes in cardiovascular, immune, metabolic, and cognitive function with age in marmosets.
Pharmacological assessment of metformin and acarbose as potential longevity interventions in marmosets.