TORwards a Victory Over Aging
January 1, 2020
Lamming DW, Salmon AB J Gerontol A Biol Sci Med Sci. 2020 Jan 1;75(1):1-3. doi: 10.1093/gerona/glz212.
Long-term treatment with the mTOR inhibitor rapamycin has minor effect on clinical laboratory markers in middle-aged marmosets.
October 12, 2018
Sills AM, Artavia JM, DeRosa BD, Ross CN, Salmon AB American Journal of Primatology. 2018 Oct 12:e22927. doi: 10.1002/ajp.22927. [Epub ahead of print]. Abstract: Interventions to extend lifespan and improve health with increasing age would have significant impact on a growing aged population. There are now several pharmaceutical interventions that extend lifespan in laboratory rodent [...]Hydrogen sulfide ameliorates aging-associated changes in the kidney.
May 1, 2018
Lee HJ, Feliers D, Barnes JL, Oh S, Choudhury GG2, Diaz V, Galvan V, Strong R, Nelson J, Salmon A, Kevil CG, Kasinath BS Geroscience. 2018 Apr;40(2):163-176. doi: 10.1007/s11357-018-0018-y. Epub 2018 May 1. PMCID: PMC5964063 Abstract Aging is associated with replacement of normal kidney parenchyma by fibrosis. Because hydrogen sulfide (H2S) ameliorates kidney fibrosis in […]
Moving toward ‘common’ use of the marmoset as a non-human primate aging model
July 22, 2016
Moving toward ‘common’ use of the marmoset as a non-human primate aging model Adam B. Salmon Pathobiol Aging Age Relat Dis. 2016; 6: 10.3402/pba.v6.32758. Published online 2016 Jul 22. doi: 10.3402/pba.v6.32758 Abstract Great leaps forward in our understanding of the basic biology of aging, including interventions that extend longevity, have come about from using common [...]Metabolic consequences of long-term rapamycin exposure on common marmoset monkeys (Callithrix jacchus).
November 1, 2015
Ross C, Salmon A, Strong R, Fernandez E, Javors M, Richardson A, Tardif S Aging (Albany NY). 2015 Nov;7(11):964-73. doi: 10.18632/aging.100843 Abstract Rapamycin has been shown to extend lifespan in rodent models, but the effects on metabolic health and function have been widely debated in both clinical and translational trials. Prior to rapamycin being used [...]Testing Efficacy of Administration of the Antiaging Drug Rapamycin in a Nonhuman Primate, the Common Marmoset
May 1, 2015
Tardif S, Ross C, Bergman P, Fernandez E, Javors M, Salmon A, Spross J, Strong R, Richardson A J Gerontol A Biol Sci Med Sci. 2015 May;70(5):577-87. doi: 10.1093/gerona/glu101. Epub 2014 Jul 19. Abstract This report is the first description of dosing procedures, pharmacokinetics, biochemical action, and general tolerability of the antiaging drug rapamycin in [...]