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3 Dec 2019 Aging Induces an Nlrp3 Inflammasome-Dependent Expansion of Adipose B Cells That Impairs Metabolic Homeostasis.

Aging Induces an Nlrp3 Inflammasome-Dependent Expansion of Adipose B Cells That Impairs Metabolic Homeostasis. Camell CD, Günther P, Lee A, Goldberg EL, Spadaro O, Youm YH, Bartke A, Hubbard GB, Ikeno Y, Ruddle NH, Schultze J, Dixit VD Cell Metab. 2019 Dec 3;30(6):1024-1039.e6. doi: 10.1016/j.cmet.2019.10.006. Epub 2019 Nov 14. Abstract: During aging, visceral adiposity is […]

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21 Nov 2019 Body image in older women: a mediator of BMI and wellness behaviors.

Body image in older women: a mediator of BMI and wellness behaviors. Kilpela LS, Verzijl CL, Becker CB J Women Aging. 2019 Nov 21:1-14. doi: 10.1080/08952841.2019.1692629. [Epub ahead of print] Abstract: Negative body image is prevalent among mid- and late-life women. In younger women, negative body image is associated with reduced quality of life (QOL) […]

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18 Nov 2019 Deficiency in the DNA repair protein ERCC1 triggers a link between senescence and apoptosis in human fibroblasts and mouse skin.

Deficiency in the DNA repair protein ERCC1 triggers a link between senescence and apoptosis in human fibroblasts and mouse skin. Kim DE, Dollé MET, Vermeij WP, Gyenis A, Vogel K, Hoeijmakers JHJ, Wiley CD, Davalos AR, Hasty P, Desprez PY, Campisi J Aging Cell. 2019 Nov 18:e13072. doi: 10.1111/acel.13072. [Epub ahead of print] Abstract: ERCC1 […]

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12 Nov 2019 Exercise preserves muscle mass and force in a prostate cancer mouse model.

Exercise preserves muscle mass and force in a prostate cancer mouse model. Patel DI, Abuchowski K, Sheikh B, Rivas P, Musi N, Kumar AP. Eur J Transl Myol. 2019 Nov 12;29(4):8520. doi: 10.4081/ejtm.2019.8520. eCollection 2019 Oct 29. Abstract: The purpose of this study was to examine the effects of exercise in modulating biomarkers of sarcopenia […]

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16 Apr 2019 Hepatic posttranscriptional network comprised of CCR4-NOT deadenylase and FGF21 maintains systemic metabolic homeostasis.

Hepatic posttranscriptional network comprised of CCR4-NOT deadenylase and FGF21 maintains systemic metabolic homeostasis Morita M, Siddiqui N, Katsumura S, Rouya C, Larsson O, Nagashima T, Hekmatnejad B, Takahashi A, Kiyonari H, Zang M, St-Arnaud R, Oike Y, Giguère V, Topisirovic I, Okada-Hatakeyama M, Yamamoto T, Sonenberg N PNAS. 2019 Apr 16;116(16):7973-7981. doi: 10.1073/pnas.1816023116. Epub 2019 […]

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25 Feb 2019 Age‐related changes in the marmoset gut microbiome

Age-related changes in the marmoset gut microbiome Reveles KR, Patel S, Forney L, Ross CN American Journal of Primatology. 2019 Feb;81(2):e22960. doi: 10.1002/ajp.22960. Epub 2019 Feb 25. Abstract The gut microbiome is known to play a significant role in human health but its role in aging remains unclear. The objective of this study was to […]

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23 Jan 2019 Rapamycin and Alzheimer’s disease: Time for a clinical trial?

Rapamycin and Alzheimer’s disease: Time for a clinical trial? Kaeberlein M, Galvan V Sci Transl Med. 2019 Jan 23;11(476). pii: eaar4289. doi: 10.1126/scitranslmed.aar4289. Abstract: The drug rapamycin has beneficial effects in a number of animal models of neurodegeneration and aging including mouse models of Alzheimer’s disease. Despite its compelling preclinical record, no clinical trials have […]

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12 Dec 2018 Effects of intravenous AICAR (5-aminoimidazole-4-carboximide riboside) administration on insulin signaling and resistance in premature baboons, Papio sp.

Effects of intravenous AICAR (5-aminoimidazole-4-carboximide riboside) administration on insulin signaling and resistance in premature baboons, Papio sp. Blanco CL, Gastaldelli A, Anzueto DG, Winter LA, Seidner SR, McCurnin DC, Liang H, Javors MA, DeFronzo RA, Musi N PLoS one. 2018 Dec 12;13(12):e0208757. doi: 10.1371/journal.pone.0208757. eCollection 2018. Abstract: Premature baboons exhibit peripheral insulin resistance and impaired […]

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13 Nov 2018 NFκB Regulates Muscle Development and Mitochondrial Function.

NFκB Regulates Muscle Development and Mitochondrial Function. Valentine JM, Li ME, Shoelson SE, Zhang N, Reddick RL, Musi N J Gerontol A Biol Sci Med Sci. 2018 Nov 13. doi: 10.1093/gerona/gly262. [Epub ahead of print] Abstract: NFκB is a transcription factor that controls immune and inflammatory signaling pathways. In skeletal muscle, NFκB has been implicated […]

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9 Nov 2018 Tau‐induced nuclear envelope invagination causes a toxic accumulation of mRNA in Drosophila

Tau‐induced nuclear envelope invagination causes a toxic accumulation of mRNA in Drosophila Cornelison GL, Levy SA, Jenson T, Frost B Aging Cell. 2018 Nov 9:e12847. doi: 10.1111/acel.12847. [Epub ahead of print] Abstract The nucleus is a spherical dual-membrane bound organelle that encapsulates genomic DNA. In eukaryotes, messenger RNAs (mRNA) are transcribed in the nucleus and […]

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