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22 Dec 2020 TREX2 Exonuclease Causes Spontaneous Mutations and Stress-Induced Replication Fork Defects in Cells Expressing RAD51K133A

TREX2 Exonuclease Causes Spontaneous Mutations and Stress-Induced Replication Fork Defects in Cells Expressing RAD51K133A Jun Ho Ko, Mi Young Son, Qing Zhou, Lucia Molnarova, Lambert Song, Jarmila Mlcouskova, Atis Jekabsons, Cristina Montagna, Lumir Krejci, Paul Hasty Cell Reports. Volume 33, Issue 12, 22 December 2020, 108543. doi: 10.1016/j.celrep.2020.108543. Summary: DNA damage tolerance (DDT) and homologous […]

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5 Nov 2020 Early disruption of nerve mitochondrial and myelin lipid homeostasis in obesity-induced diabetes

Early disruption of nerve mitochondrial and myelin lipid homeostasis in obesity-induced diabetes. Juan P Palavicini, Juan Chen, Chunyan Wang, Jianing Wang, Chao Qin, Eric Baeuerle, Xinming Wang, Jung A Woo, David E Kang, Nicolas Musi, Jeffrey L Dupree, Xianlin Han. JCI Insight. 2020 Nov 5;5(21):137286. doi: 10.1172/jci.insight.137286. Abstract: Diabetic neuropathy is a major complication of […]

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14 Jul 2020 Pathogenic Tau Causes a Toxic Depletion of Nuclear Calcium

Pathogenic Tau Causes a Toxic Depletion of Nuclear Calcium. Rebekah Mahoney, Elizabeth Ochoa Thomas, Paulino Ramirez, Henry E Miller, Adrian Beckmann, Gabrielle Zuniga, Radek Dobrowolski, Bess Frost. Cell Reports. 2020 Jul 14;32(2):107900. doi: 10.1016/j.celrep.2020.107900. Abstract: Synaptic activity-induced calcium (Ca2+) influx and subsequent propagation into the nucleus is a major way in which synapses communicate with […]

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1 Apr 2020 Awakening the dark side: retrotransposon activation in neurodegenerative disorders

Awakening the dark side: retrotransposon activation in neurodegenerative disorders. Elizabeth Ochoa Thomas, Gabbe Zuniga, Wenyan Sun, Bess Frost. Current Opinion in Neurobiology. 2020 Apr;61:65-72. doi: 10.1016/j.conb.2020.01.012. Epub 2020 Feb 21. Abstract: Nearly half (45%) of the human genome is composed of transposable elements, or ‘jumping genes’. Since Barbara McClintock’s original discovery of transposable elements in […]

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21 Jan 2020 mTOR drives cerebrovascular, synaptic, and cognitive dysfunction in normative aging.

mTOR drives cerebrovascular, synaptic, and cognitive dysfunction in normative aging. Van Skike CE, Lin AL, Roberts Burbank R, Halloran JJ, Hernandez SF, Cuvillier J, Soto VY, Hussong SA, Jahrling JB, Javors MA, Hart MJ, Fischer KE, Austad SN, Galvan V. Aging Cell. 2020 Jan;19(1):e13057. doi: 10.1111/acel.13057. Epub 2019 Nov 6. Abstract: Cerebrovascular dysfunction and cognitive […]

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13 Jan 2020 Age-dependent autophagy induction after injury promotes axon regeneration by limiting NOTCH.

Age-dependent autophagy induction after injury promotes axon regeneration by limiting NOTCH. Ko SH, Apple EC, Liu Z, Chen L Autophagy. 2020 Jan 13:1-17. doi: 10.1080/15548627.2020.1713645. [Epub ahead of print] Abstract: Macroautophagy/autophagy is essential for maintaining cellular homeostasis through the degradation of organelles and proteins. It also has a prominent role in modulating aging. However, the […]

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6 Jan 2020 Acarbose improved survival for Apc+/Min mice.

Acarbose improved survival for Apc+/Min mice. Dodds SG, Parihar M, Javors M, Nie J, Musi N, Dave Sharp Z, Hasty P Aging Cell. 2020 Jan 6:e13088. doi: 10.1111/acel.13088. [Epub ahead of print] Abstract: Acarbose blocks the digestion of complex carbohydrates, and the NIA Intervention Testing Program (ITP) found that it improved survival when fed to […]

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1 Jan 2020 TORwards a Victory Over Aging

TORwards a Victory Over Aging. Lamming DW, Salmon AB J Gerontol A Biol Sci Med Sci. 2020 Jan 1;75(1):1-3. doi: 10.1093/gerona/glz212.

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30 Dec 2019 APOE2 orchestrated differences in transcriptomic and lipidomic profiles of postmortem AD brain.

APOE2 orchestrated differences in transcriptomic and lipidomic profiles of postmortem AD brain. Lefterov I, Wolfe CM, Fitz NF, Nam KN, Letronne F, Biedrzycki RJ, Kofler J, Han X, Wang J, Schug J, Koldamova R Alzheimers Res Ther. 2019 Dec 30;11(1):113. doi: 10.1186/s13195-019-0558-0. Abstract: BACKGROUND: The application of advanced sequencing technologies and improved mass-spectrometry platforms revealed […]

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19 Dec 2019 Nexrutine and exercise similarly prevent high grade prostate tumors in transgenic mouse model.

Nexrutine and exercise similarly prevent high grade prostate tumors in transgenic mouse model. Patel DI, Abuchowski K, Bedolla R, Rivas P, Musi N, Reddick R, Kumar AP PLoS One. 2019 Dec 19;14(12):e0226187. doi: 10.1371/journal.pone.0226187. eCollection 2019. Abstract: The purpose of this investigation was to compare the antitumorigenic effects of the natural product Nexrutine to voluntary […]

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