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14 Jul 2020 Pathogenic Tau Causes a Toxic Depletion of Nuclear Calcium

Pathogenic Tau Causes a Toxic Depletion of Nuclear Calcium. Rebekah Mahoney, Elizabeth Ochoa Thomas, Paulino Ramirez, Henry E Miller, Adrian Beckmann, Gabrielle Zuniga, Radek Dobrowolski, Bess Frost. Cell Reports. 2020 Jul 14;32(2):107900. doi: 10.1016/j.celrep.2020.107900. Abstract: Synaptic activity-induced calcium (Ca2+) influx and subsequent propagation into the nucleus is a major way in which synapses communicate with […]

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1 Apr 2020 Awakening the dark side: retrotransposon activation in neurodegenerative disorders

Awakening the dark side: retrotransposon activation in neurodegenerative disorders. Elizabeth Ochoa Thomas, Gabbe Zuniga, Wenyan Sun, Bess Frost. Current Opinion in Neurobiology. 2020 Apr;61:65-72. doi: 10.1016/j.conb.2020.01.012. Epub 2020 Feb 21. Abstract: Nearly half (45%) of the human genome is composed of transposable elements, or ‘jumping genes’. Since Barbara McClintock’s original discovery of transposable elements in […]

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21 Jan 2020 mTOR drives cerebrovascular, synaptic, and cognitive dysfunction in normative aging.

mTOR drives cerebrovascular, synaptic, and cognitive dysfunction in normative aging. Van Skike CE, Lin AL, Roberts Burbank R, Halloran JJ, Hernandez SF, Cuvillier J, Soto VY, Hussong SA, Jahrling JB, Javors MA, Hart MJ, Fischer KE, Austad SN, Galvan V. Aging Cell. 2020 Jan;19(1):e13057. doi: 10.1111/acel.13057. Epub 2019 Nov 6. Abstract: Cerebrovascular dysfunction and cognitive […]

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13 Jan 2020 Age-dependent autophagy induction after injury promotes axon regeneration by limiting NOTCH.

Age-dependent autophagy induction after injury promotes axon regeneration by limiting NOTCH. Ko SH, Apple EC, Liu Z, Chen L Autophagy. 2020 Jan 13:1-17. doi: 10.1080/15548627.2020.1713645. [Epub ahead of print] Abstract: Macroautophagy/autophagy is essential for maintaining cellular homeostasis through the degradation of organelles and proteins. It also has a prominent role in modulating aging. However, the […]

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6 Jan 2020 Acarbose improved survival for Apc+/Min mice.

Acarbose improved survival for Apc+/Min mice. Dodds SG, Parihar M, Javors M, Nie J, Musi N, Dave Sharp Z, Hasty P Aging Cell. 2020 Jan 6:e13088. doi: 10.1111/acel.13088. [Epub ahead of print] Abstract: Acarbose blocks the digestion of complex carbohydrates, and the NIA Intervention Testing Program (ITP) found that it improved survival when fed to […]

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1 Jan 2020 TORwards a Victory Over Aging

TORwards a Victory Over Aging. Lamming DW, Salmon AB J Gerontol A Biol Sci Med Sci. 2020 Jan 1;75(1):1-3. doi: 10.1093/gerona/glz212.

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30 Dec 2019 APOE2 orchestrated differences in transcriptomic and lipidomic profiles of postmortem AD brain.

APOE2 orchestrated differences in transcriptomic and lipidomic profiles of postmortem AD brain. Lefterov I, Wolfe CM, Fitz NF, Nam KN, Letronne F, Biedrzycki RJ, Kofler J, Han X, Wang J, Schug J, Koldamova R Alzheimers Res Ther. 2019 Dec 30;11(1):113. doi: 10.1186/s13195-019-0558-0. Abstract: BACKGROUND: The application of advanced sequencing technologies and improved mass-spectrometry platforms revealed […]

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19 Dec 2019 Nexrutine and exercise similarly prevent high grade prostate tumors in transgenic mouse model.

Nexrutine and exercise similarly prevent high grade prostate tumors in transgenic mouse model. Patel DI, Abuchowski K, Bedolla R, Rivas P, Musi N, Reddick R, Kumar AP PLoS One. 2019 Dec 19;14(12):e0226187. doi: 10.1371/journal.pone.0226187. eCollection 2019. Abstract: The purpose of this investigation was to compare the antitumorigenic effects of the natural product Nexrutine to voluntary […]

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3 Dec 2019 Aging Induces an Nlrp3 Inflammasome-Dependent Expansion of Adipose B Cells That Impairs Metabolic Homeostasis.

Aging Induces an Nlrp3 Inflammasome-Dependent Expansion of Adipose B Cells That Impairs Metabolic Homeostasis. Camell CD, Günther P, Lee A, Goldberg EL, Spadaro O, Youm YH, Bartke A, Hubbard GB, Ikeno Y, Ruddle NH, Schultze J, Dixit VD Cell Metab. 2019 Dec 3;30(6):1024-1039.e6. doi: 10.1016/j.cmet.2019.10.006. Epub 2019 Nov 14. Abstract: During aging, visceral adiposity is […]

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21 Nov 2019 Body image in older women: a mediator of BMI and wellness behaviors.

Body image in older women: a mediator of BMI and wellness behaviors. Kilpela LS, Verzijl CL, Becker CB J Women Aging. 2019 Nov 21:1-14. doi: 10.1080/08952841.2019.1692629. [Epub ahead of print] Abstract: Negative body image is prevalent among mid- and late-life women. In younger women, negative body image is associated with reduced quality of life (QOL) […]

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