Publications

TREX2 Exonuclease Causes Spontaneous Mutations and Stress-Induced Replication Fork Defects in Cells Expressing RAD51K133A

July 7, 2021

Jun Ho Ko, Mi Young Son, Qing Zhou, Lucia Molnarova, Lambert Song, Jarmila Mlcouskova, Atis Jekabsons, Cristina Montagna, Lumir Krejci, Paul Hasty Cell Reports. Volume 33, Issue 12, 22 December 2020, 108543. doi: 10.1016/j.celrep.2020.108543. Summary: DNA damage tolerance (DDT) and homologous recombination (HR) stabilize replication forks (RFs). RAD18/UBC13/three prime repair exonuclease 2 (TREX2)-mediated proliferating cell […]

Early disruption of nerve mitochondrial and myelin lipid homeostasis in obesity-induced diabetes

November 5, 2020

Juan P Palavicini, Juan Chen, Chunyan Wang, Jianing Wang, Chao Qin, Eric Baeuerle, Xinming Wang, Jung A Woo, David E Kang, Nicolas Musi, Jeffrey L Dupree, Xianlin Han. JCI Insight. 2020 Nov 5;5(21):137286. doi: 10.1172/jci.insight.137286. Abstract: Diabetic neuropathy is a major complication of diabetes. Current treatment options alleviate pain but do not stop the progression […]

Pathogenic Tau Causes a Toxic Depletion of Nuclear Calcium

July 14, 2020

Rebekah Mahoney, Elizabeth Ochoa Thomas, Paulino Ramirez, Henry E Miller, Adrian Beckmann, Gabrielle Zuniga, Radek Dobrowolski, Bess Frost. Cell Reports. 2020 Jul 14;32(2):107900. doi: 10.1016/j.celrep.2020.107900. Abstract: Synaptic activity-induced calcium (Ca2+) influx and subsequent propagation into the nucleus is a major way in which synapses communicate with the nucleus to regulate transcriptional programs important for activity-dependent […]

Awakening the dark side: retrotransposon activation in neurodegenerative disorders

April 1, 2020

Elizabeth Ochoa Thomas, Gabbe Zuniga, Wenyan Sun, Bess Frost. Current Opinion in Neurobiology. 2020 Apr;61:65-72. doi: 10.1016/j.conb.2020.01.012. Epub 2020 Feb 21. Abstract: Nearly half (45%) of the human genome is composed of transposable elements, or ‘jumping genes’. Since Barbara McClintock’s original discovery of transposable elements in 1950, we have come to appreciate that transposable element […]

mTOR drives cerebrovascular, synaptic, and cognitive dysfunction in normative aging.

January 21, 2020

Van Skike CE, Lin AL, Roberts Burbank R, Halloran JJ, Hernandez SF, Cuvillier J, Soto VY, Hussong SA, Jahrling JB, Javors MA, Hart MJ, Fischer KE, Austad SN, Galvan V. Aging Cell. 2020 Jan;19(1):e13057. doi: 10.1111/acel.13057. Epub 2019 Nov 6. Abstract: Cerebrovascular dysfunction and cognitive decline are highly prevalent in aging, but the mechanisms underlying […]

Age-dependent autophagy induction after injury promotes axon regeneration by limiting NOTCH.

January 13, 2020

Ko SH, Apple EC, Liu Z, Chen L Autophagy. 2020 Jan 13:1-17. doi: 10.1080/15548627.2020.1713645. [Epub ahead of print] Abstract: Macroautophagy/autophagy is essential for maintaining cellular homeostasis through the degradation of organelles and proteins. It also has a prominent role in modulating aging. However, the role of autophagy in the neuronal response to axon injury and […]

Acarbose improved survival for Apc+/Min mice.

January 6, 2020

Dodds SG, Parihar M, Javors M, Nie J, Musi N, Dave Sharp Z, Hasty P Aging Cell. 2020 Jan 6:e13088. doi: 10.1111/acel.13088. [Epub ahead of print] Abstract: Acarbose blocks the digestion of complex carbohydrates, and the NIA Intervention Testing Program (ITP) found that it improved survival when fed to mice. Yet, we do not know […]

TORwards a Victory Over Aging

January 1, 2020

Lamming DW, Salmon AB J Gerontol A Biol Sci Med Sci. 2020 Jan 1;75(1):1-3. doi: 10.1093/gerona/glz212.

APOE2 orchestrated differences in transcriptomic and lipidomic profiles of postmortem AD brain.

December 30, 2019

Lefterov I, Wolfe CM, Fitz NF, Nam KN, Letronne F, Biedrzycki RJ, Kofler J, Han X, Wang J, Schug J, Koldamova R Alzheimers Res Ther. 2019 Dec 30;11(1):113. doi: 10.1186/s13195-019-0558-0. Abstract: BACKGROUND: The application of advanced sequencing technologies and improved mass-spectrometry platforms revealed significant changes in gene expression and lipids in Alzheimer’s disease (AD) brain. […]

Nexrutine and exercise similarly prevent high grade prostate tumors in transgenic mouse model.

December 19, 2019

Patel DI, Abuchowski K, Bedolla R, Rivas P, Musi N, Reddick R, Kumar AP PLoS One. 2019 Dec 19;14(12):e0226187. doi: 10.1371/journal.pone.0226187. eCollection 2019. Abstract: The purpose of this investigation was to compare the antitumorigenic effects of the natural product Nexrutine to voluntary wheel running (VWR) in the transgenic adenocarcinoma of the mouse prostate (TRAMP) model. […]