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13 Jan 2020 Age-dependent autophagy induction after injury promotes axon regeneration by limiting NOTCH.

Age-dependent autophagy induction after injury promotes axon regeneration by limiting NOTCH. Ko SH, Apple EC, Liu Z, Chen L Autophagy. 2020 Jan 13:1-17. doi: 10.1080/15548627.2020.1713645. [Epub ahead of print] Abstract: Macroautophagy/autophagy is essential for maintaining cellular homeostasis through the degradation of organelles and proteins. It also has a prominent role in modulating aging. However, the […]

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6 Jan 2020 Acarbose improved survival for Apc+/Min mice.

Acarbose improved survival for Apc+/Min mice. Dodds SG, Parihar M, Javors M, Nie J, Musi N, Dave Sharp Z, Hasty P Aging Cell. 2020 Jan 6:e13088. doi: 10.1111/acel.13088. [Epub ahead of print] Abstract: Acarbose blocks the digestion of complex carbohydrates, and the NIA Intervention Testing Program (ITP) found that it improved survival when fed to […]

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1 Jan 2020 TORwards a Victory Over Aging

TORwards a Victory Over Aging. Lamming DW, Salmon AB J Gerontol A Biol Sci Med Sci. 2020 Jan 1;75(1):1-3. doi: 10.1093/gerona/glz212.

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30 Dec 2019 APOE2 orchestrated differences in transcriptomic and lipidomic profiles of postmortem AD brain.

APOE2 orchestrated differences in transcriptomic and lipidomic profiles of postmortem AD brain. Lefterov I, Wolfe CM, Fitz NF, Nam KN, Letronne F, Biedrzycki RJ, Kofler J, Han X, Wang J, Schug J, Koldamova R Alzheimers Res Ther. 2019 Dec 30;11(1):113. doi: 10.1186/s13195-019-0558-0. Abstract: BACKGROUND: The application of advanced sequencing technologies and improved mass-spectrometry platforms revealed […]

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19 Dec 2019 Nexrutine and exercise similarly prevent high grade prostate tumors in transgenic mouse model.

Nexrutine and exercise similarly prevent high grade prostate tumors in transgenic mouse model. Patel DI, Abuchowski K, Bedolla R, Rivas P, Musi N, Reddick R, Kumar AP PLoS One. 2019 Dec 19;14(12):e0226187. doi: 10.1371/journal.pone.0226187. eCollection 2019. Abstract: The purpose of this investigation was to compare the antitumorigenic effects of the natural product Nexrutine to voluntary […]

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3 Dec 2019 Aging Induces an Nlrp3 Inflammasome-Dependent Expansion of Adipose B Cells That Impairs Metabolic Homeostasis.

Aging Induces an Nlrp3 Inflammasome-Dependent Expansion of Adipose B Cells That Impairs Metabolic Homeostasis. Camell CD, Günther P, Lee A, Goldberg EL, Spadaro O, Youm YH, Bartke A, Hubbard GB, Ikeno Y, Ruddle NH, Schultze J, Dixit VD Cell Metab. 2019 Dec 3;30(6):1024-1039.e6. doi: 10.1016/j.cmet.2019.10.006. Epub 2019 Nov 14. Abstract: During aging, visceral adiposity is […]

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21 Nov 2019 Body image in older women: a mediator of BMI and wellness behaviors.

Body image in older women: a mediator of BMI and wellness behaviors. Kilpela LS, Verzijl CL, Becker CB J Women Aging. 2019 Nov 21:1-14. doi: 10.1080/08952841.2019.1692629. [Epub ahead of print] Abstract: Negative body image is prevalent among mid- and late-life women. In younger women, negative body image is associated with reduced quality of life (QOL) […]

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18 Nov 2019 Deficiency in the DNA repair protein ERCC1 triggers a link between senescence and apoptosis in human fibroblasts and mouse skin.

Deficiency in the DNA repair protein ERCC1 triggers a link between senescence and apoptosis in human fibroblasts and mouse skin. Kim DE, Dollé MET, Vermeij WP, Gyenis A, Vogel K, Hoeijmakers JHJ, Wiley CD, Davalos AR, Hasty P, Desprez PY, Campisi J Aging Cell. 2019 Nov 18:e13072. doi: 10.1111/acel.13072. [Epub ahead of print] Abstract: ERCC1 […]

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12 Nov 2019 Exercise preserves muscle mass and force in a prostate cancer mouse model.

Exercise preserves muscle mass and force in a prostate cancer mouse model. Patel DI, Abuchowski K, Sheikh B, Rivas P, Musi N, Kumar AP. Eur J Transl Myol. 2019 Nov 12;29(4):8520. doi: 10.4081/ejtm.2019.8520. eCollection 2019 Oct 29. Abstract: The purpose of this study was to examine the effects of exercise in modulating biomarkers of sarcopenia […]

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16 Apr 2019 Hepatic posttranscriptional network comprised of CCR4-NOT deadenylase and FGF21 maintains systemic metabolic homeostasis.

Hepatic posttranscriptional network comprised of CCR4-NOT deadenylase and FGF21 maintains systemic metabolic homeostasis Morita M, Siddiqui N, Katsumura S, Rouya C, Larsson O, Nagashima T, Hekmatnejad B, Takahashi A, Kiyonari H, Zang M, St-Arnaud R, Oike Y, Giguère V, Topisirovic I, Okada-Hatakeyama M, Yamamoto T, Sonenberg N PNAS. 2019 Apr 16;116(16):7973-7981. doi: 10.1073/pnas.1816023116. Epub 2019 […]

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